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Tiamina, vitamin pertama yang ditemukan, adalah vitamin B yang ditemukan dalam makanan seperti kacang-kacangan, daging, biji-bijian utuh, dan polong-polongan. Tiamina, yang disebut juga vitamin B1, merupakan nutrien yang esensial untuk fungsi dan pertumbuhan sel yang baik. Benfotiamina merupakan versi tiamina sintetis atau dibuat di laboratorium. Ilmuwan meneliti benfotiamina untuk menentukan kemungkinan manfaatnya dalam membantu kondisi ketika defisiensi B1 menyebabkan atau memperberat gejala penyakit.
Tiamina merupakan mikronutrien esensial yang membantu tubuh menghasilkan protein dan lemak sekaligus membantu metabolisme karbohidrat. Vitamin B1 juga membantu tubuh dengan mengubah energi makanan menjadi bahan bakar untuk sistem kardiovaskular dan sistem saraf sehingga mendukung jantung, otak, dan saraf.
Walaupun kadar tiamin yang rendah jarang terjadi di negara berkembang, defisiensi dapat dikaitkan dengan kondisi kesehatan seperti penyakit Alzheimer, diabetes, dan ketergantungan alkohol. Karena merupakan bentuk larut-lemak tiamina, benfotiamina memiliki laju penyerapan yang lebih tinggi dibandingkan bentuk alami vitamin B1 yang larut-air. Laju penyerapan yang lebih tinggi dapat membantunya merawat kondisi yang berkaitan dengan defisiensi tiamina, seperti neuropati diabetik.
Dengan laju penyerapan yang lebih baik dibandingkan tiamina alami, benfotiamina memiliki beberapa manfaat kesehatan dalam tubuh.
Karena ketersediaan hayatinya yang lebih tinggi, benfotiamina dapat membantu mengurangi gejala yang berkaitan dengan defisiensi vitamin B1.
Meskipun jarang terjadi di negara industri, seperti disebutkan di atas, orang yang menderita ketergantungan alkohol, gangguan makan, pola makan yang buruk, akses terbatas ke makanan bergizi, penyakit ginjal, atau diare memiliki risiko meningkat untuk mengalami defisiensi tiamina. Orang yang juga berisiko mengalami defisiensi vitamin B1 adalah orang yang mengalami penurunan berat badan atau menjalani bedah pintas lambung, hamil atau menyusui, menderita hipertiroidisme atau HIV/AIDS, atau menggunakan diuretik atau obat yang menyebabkan kehilangan cairan. Mengunyah kacang betel/areca secara rutin serta sering mengonsumsi ikan mentah atau kerang-kerangan juga dapat ikut berkontribusi menyebabkan defisiensi.
Gejala defisiensi tiamina yang dapat ditolong dengan suplemen benfotiamina antara lain:
If left untreated or if thiamine deficiency is severe, complications—including coma, heart failure, permanent nerve damage, or psychosis—can occur. Symptoms such as difficulty breathing, inability to speak, and paralysis are life-threatening and need emergency medical attention.
Two major health concerns that can result from thiamine deficiency include Wernicke-Korsakoff syndrome and beriberi. Beriberi is caused by a buildup of pyruvic acid in the blood. Pyruvic acid is a byproduct of your body’s inability to convert food into fuel due to a lack of vitamin B1. Symptoms of beriberi include difficulty breathing; irregular eye movement and heart function; pain; vomiting; loss of sensation or feeling; and decreased alertness.
Wernicke-Korsakoff syndrome comprises two separate diseases. Wernicke’s disease can progress to Korsakoff syndrome if left untreated. Wernicke’s disease presents with muscle weakness, visual impairment, and mental deterioration due to the effects on the nervous system. Korsakoff syndrome presents with irreversible memory impairment and difficulties learning new information.
Evidence shows that thiamine and other nutrients combined may help reduce your risk of developing cataracts.
Optic neuropathy is associated with thiamine deficiency. Symptoms include loss of light perception and severe vision loss. Supplementing with benfotiamine could help improve optic neuropathy symptoms more quickly than thiamine supplements due to benfotiamine’s increased absorption rate.
Uveitis, which is inflammation of the tissue below the outer surface of the eyeball, is one of the leading causes of blindness around the world. Researchers from the University of Texas Medical Branch published the results of a study they conducted that demonstrated remarkable results with benfotiamine in the treatment of uveitis. The researchers found that laboratory rats injected with bacterial toxins that typically produce a uveitis-like reaction fail to develop any symptoms of the disorder when fed benfotiamine.
"Benfotiamine strongly suppresses this eye-damaging condition and the biochemical markers we associate with it," said UTMB associate professor Kota Ramana, senior author of the study. "We're optimistic that this simple supplementation with vitamin B1 has great potential as a new therapy for this widespread eye disease."
Many diabetics are deficient in thiamine, an important cofactor in carbohydrate metabolism.
Thiamine deficiency can cause oxidative stress, inflammation, and dysfunction of the endothelial lining or the lining of the inner wall of the blood vessels causing them to constrict or narrow. Oxidative stress is the imbalance of free radicals that cause tissue damage, and antioxidants that defend against or repair free radical damage.
Benfotiamine supplementation can help prevent harmful by-products of glucose metabolism. Supplementation of this fat-soluble B vitamin can also reduce oxidative stress and improve endothelial function.
In thiamine deficiency, glucose is metabolized differently. This alternative pathway of carbohydrate metabolism can cause vascular damage. Benfotiamine supplements can help decrease or prevent the need for this alternative metabolic process, thereby reducing the risk of vascular damage in diabetics.
Both thiamine levels and activity related to thiamine-dependent enzymes are decreased in the tissues and brains of those with Alzheimer’s disease.
Clinical trials have demonstrated improvement in cognitive function of patients with Alzheimer’s taking thiamine oral supplementation. Due to the poor absorption of thiamine in the elderly population, supplementation with benfotiamine could be an alternative option, especially considering it is more easily absorbed compared to its water-soluble counterpart.
Even though the human brain represents only 2 percent of your body weight, it uses around 20 percent of your total body glucose. Thiamine plays a vital role in glucose metabolism. Evidence shows that patients with Alzheimer’s may have reduced glucose utilization as much as 30 years before dementia symptoms begin.
A small clinical trial conducted at the Burke Neurological institute concluded that benfotiamine is safe and potentially effective at improving cognitive outcomes in those suffering from mild Alzheimer’s. Benfotiamine raises vitamin B1 levels, which improves brain glucose utilization.
By increasing glucose utilization with benfotiamine, we may be able to slow or stop memory decline or dementia in patients with Alzheimer’s disease.
Urinary albumin excretion (UAE) was used as a marker of renal function in a study focused on diabetic patients with kidney dysfunction. The study found that UAE was decreased in patients receiving thiamin therapy compared to no significant decrease in patients receiving placebo.
Another study considered how glucose and its metabolites may damage the peritoneum and help deteriorate the remnant kidney and looked at the effects of benfotiamine supplementation in patients receiving peritoneal dialysis. The study found benfotiamine decreased glucose-induced tissue damage. This study used rats on peritoneal dialysis. Other findings include decreased peritoneal fibrosis, inflammation markers, neovascularization, or the development of new blood vessels. Together, these led to improved peritoneal transport.
In addition, the benfotiamine-treated rats demonstrated lower levels of harmful by-products from glucose metabolism, reduced glomerular damage, and less albuminuria. Each of these findings is a positive indicator of improved renal function and suggests benfotiamine protects the peritoneal membrane and remnant kidney in a rat model of peritoneal dialysis.
Benfotiamine appears to be safe and side effects are rare. However, some potential side effects exist. These include skin rash, nausea, and upset stomach.
A typical dose of benfotiamine is 150-600 mg by mouth daily for up to 6 months for adults.
A fat-soluble form of thiamine or vitamin B1, benfotiamine is showing promise as a more readily absorbable form of this all-important micronutrient.
Researchers have found that benfotiamine may help with a number of conditions, including Alzheimer’s disease, diabetes, kidney disease, and chronic eye illnesses.
With thiamine playing various critical roles in human physiology, a more bioavailable form of it can be vital for your health and well-being.
Thiamine deficiency is rare in industrialized nations, but conditions such as eating disorders, alcoholism, pregnancy, and gastric bypass surgery can put you at risk. Also, those taking diuretic medications are at higher risk of thiamine deficiency. If thiamine deficiency does occur, benfotiamine, a more easily absorbable form due to its fat-soluble nature, could help alleviate deficiency symptoms, including tachycardia, seizure, mood swings, motor dysfunction, and more.
Always consult a health care professional prior to taking benfotiamine or any other dietary supplement.
Referensi:
Oleh Dr. Carlie Biggins, N.D.
